Australian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.

Adverse reactions to N-acetylcysteine are reported in 6% to 23% of patients who are administered the antidote for treatment of paracetamol poisoning.1 Because paracetamol is the most common pharmaceutical product taken in overdose in many countries, it is essential that attempts be made to prevent or minimize adverse effects caused by N-acetylcysteine. We congratulate Kerr et al2 on their attempt to address this important issue.